Cyp46a1 protein

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August undefined, 2024

WebJul 7, 2024 · CYP46A1 controls cholesterol elimination and turnover in the brain, the two processes that determine the rate of brain sterol flux through the plasma membranes and thereby the properties of these membranes. ... Further studies are required to determine whether protein acetylation is affected by CYP46A1 activity or brain sterol flux. The … WebSummary Gene: Cyp46a1 (cytochrome P450, family 46, subfamily a, polypeptide 1) Rattus norvegicus Add Watcher Analyze General Array IDs Annotation Click to see Annotation Detail View Disease Annotations Click to see Annotation Detail View Alzheimer's disease (ISO) Gene-Chemical Interaction Annotations Click to see Annotation Detail View

ATAD3A oligomerization promotes neuropathology and cognitive …

WebJan 1, 2024 · Consistent with HMGCR, CYP46A1 protein level was up-regulated in response to Aβ treatment. Based on our findings, we can suggest that increased expression of CYP46A1 level can be a regulatory positive feedback to keep neurons active in order to inhibit cholesterol accumulation in case of increased levels of HMGCR protein and … WebOct 29, 2024 · CYP46A1 mRNA is predominantly expressed within the brain (A) but not in the periphery (B). Brain expression is highest in the striatum > cortex > hippocampus > cerebellum. Box plots are shown as median … small above ground glass pool

PDB 7ls3 structure summary ‹ Protein Data Bank in Europe (PDBe) …

WebMar 2, 2024 · This aberrant oligomerization of ATAD3A induced AD-like hyperconnectivity of MAMs and impaired neuronal cholesterol turnover by inhibiting CYP46A1 (Cytochrome P450 Family 46 Subfamily A Member 1)... WebThe tissue cell type section describes the cell type specificity profile of each gene within a given tissue based on an integrative co-expression analysis of bulk RNAseq data. … WebRecombinant Human CYP46A1 Protein [H00010858-Q01] - 12.5% SDS-PAGE Stained with Coomassie Blue. Product Details. Summary. Reactivity: Hu Species Glossary: Applications: WB, ELISA, PA, AP: Order Details 100% Guarantee on every product. Recombinant Human CYP46A1 GST (N-Term) Protein Summary ... solid gold mens watches

CYP46A1, the rate-limiting enzyme for cholesterol …

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WebApr 18, 2024 · CYP46A1 transcription was found to be insensitive to major regulatory axes, except oxidative stress . Studies show that CYP46A1 may be controlled epigenetically … WebThe Cyp46a1 gene, which encodes cholesterol 24-hydroxylase, is expressed in only a small but specific subset of neurons in the brain. It was recently found that mice … solid gold name necklaces for womenWebMar 22, 2024 · When Cyp46A1 was overexpressed in NIH3T3 cells, intrinsic oxysterols increased in the order 24S-HC > 25-HC > 27-HC. We investigated the mechanism regulating the production of endogenous oxysterols in NIH3T3 cells by Cyp46A1 and found that the mRNA, relative protein levels and enzymatic activity of Cyp46A1, and the amounts of … solid gold minneapolis club

"WebNov 16, 2024 · The crystal structure of human CYP46A1 P450 with ligand cholesterol-3-sulphate bound (PDB: 2Q9F; X-ray diffraction 1.9 Å) and unliganded structure of the … " - Cyp46a1 protein

Cyp46a1 protein

Amyloid beta increases ABCA1 and HMGCR protein

WebCytochrome P450 46A1 (CYP46A1) is a microsomal enzyme and cholesterol 24-hydroxylase that controls cholesterol elimination from the brain. This P450 is also a potential target for Alzheimer disease because it can be activated pharmacologically by some marketed drugs, as exemplified by efavirenz, the anti-HIV medication. Previously, we … WebCyp46a1 Name: cytochrome P450, family 46, subfamily a, polypeptide 1 Synonyms: Cyp46, cholestrol 24-hydroxylase. ... GSK3B interacting protein Synonyms: 4933433P14Rik. View Data Order Mice. Log in to follow Production Status. Production and phenotyping are currently not planned for a knockout strain of this gene. ...

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WebSep 22, 2024 · CYP46A1. cytochrome P450 family 46 subfamily A member 1. Gene ID: 10858, updated on 22-Sep-2024. Gene type: protein coding. Also known as: CP46; … WebCYP46A1 protein levels were decreased in the putamen, but not cerebral cortex samples, of post-mortem Huntington's disease patients when compared to …

WebCYP46A1 Protein Overview Lund et al. (1999) used expression cloning to isolate cDNAs that encode murine and human cholesterol 24-hydroxylases. DNA sequence analysis indicated that both proteins are localized to the endoplasmic reticulum, share 95% identity, and represent a new cytochrome P450 subfamily (CYP46). • Human CYP46A1 genome location and CYP46A1 gene details page in the UCSC Genome Browser. • UniProt entry on Cholesterol-24 hydroxylase • HMDB Database entry • RCSB Protein Data Bank Entry

WebCYP46A1 Protein Overview. Lund et al. (1999) used expression cloning to isolate cDNAs that encode murine and human cholesterol 24-hydroxylases. DNA sequence … WebCYP46A1 is part of cluster 3 Plasmacytoid DCs - Unknown function with confidence i ... Protein tyrosine phosphatase receptor type S: 0.9430: 3: UGCG: UDP-glucose ceramide glucosyltransferase: 0.9430: 3: TPM2: Tropomyosin 2: 0.9346: 3: SLC35F3: Solute carrier family 35 member F3: 0.9279: 3: CUX2: Cut like homeobox 2:

WebAnti-CYP46A1抗体. Product Properties. Cat Code Product Name Clonality Cross reactivity Application MW(kDa). 508573 Anti-CYP46A1 Rabbit pAb Rabbit pAb Human,Mouse,Rat WB 57kDa. Sensitivity . Anti-CYP46A1抗体Immunogen Recombinant protein of human CYP46A1. Host Rabbit. Clone Number . Anti-CYP46A1抗体Antibody type Polyclonal …

WebThis endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. ... CYP46A1 open_in_new. Ensembl ID . ENST00000261835 ... small above ground heated poolWebApr 1, 2024 · Reduced Cyp46A1 level at terminal stages of prion disease in prion-infected mice and sCJD patients. To assess a potential role of Cyp46A1 in prion disease, we analyzed its protein levels at the terminal stage of prion disease after intracerebral (i.c.) inoculation of three well established scrapie strains (RML, 22L and ME7) into FVB mice. solid gold mustard seed necklaceWebThis protein was produced in an in vitro wheat germ expression system that should preserve correct conformational folding that is necessary for biological function. While it … solid gold moon necklaceWebAug 4, 2024 · Cytochrome P450 46A1 (CYP46A1, cholesterol 24-hydroxylase) is the enzyme responsible for the majority of cholesterol elimination from the brain. Previously, we found that the anti-HIV drug efavirenz (EFV) can pharmacologically activate CYP46A1 in … small above ground fiberglass poolsWebNov 22, 2024 · CYP46A1 is a brain-specific enzyme responsible for cholesterol homeostasis. Inhibition of CYP46A1 activity serves as a therapeutic target for excitatory neurotoxicity. Sesame is a common medicine and food resource; its component lignans possess various pharmacological activities. In this study, the inhibitory effects of sesame … solid gold monopoly setWebNov 16, 2024 · The crystal structure of human CYP46A1 P450 with ligand cholesterol-3-sulphate bound (PDB: 2Q9F; X-ray diffraction 1.9 Å) and unliganded structure of the same protein (PDB: 2Q9G; X-ray diffraction … solid gold money clipsWebCholesterol 24-hydroxylase (CH24H or CYP46A1) is a brain-specific cytochrome P450 enzyme that metabolizes cholesterol into 24S-hydroxycholesterol (24HC) for regulating brain cholesterol homeostasis. solid gold night club