Canine model of pacing-induced heart failure
WebAug 17, 2011 · In addition, Nikolaidis et al. reported a 31% reduction in GLUT4 translocation and subsequently decreased glucose uptake, which was attributed to myocardial insulin resistance in their canine model of pacing-induced end-stage HF. However, it should be noted that their animal model was paced for a shorter duration (35 days) and at a ... WebMay 10, 2016 · In pacing-induced canine models of heart failure, marked upregulation of adenosine A1 receptors occurs with increased sensitivity to adenosine induced SN dysfunction and AF. 67. Download figure; Download PowerPoint; Figure 4. Rhythm strip showing the effect of adenosine on the sinus node and atrium. Intravenous adenosine …
Canine model of pacing-induced heart failure
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WebMar 20, 2001 · The canine pacing-induced heart failure model shows a pattern of E-C coupling changes similar to that of humans: I Ca,L of normal amplitude triggers Ca i transients and contractions much smaller than normal, whereas SR Ca uptake is markedly impaired. 11 The present study investigates whether the defect in E-C coupling is due to … WebJun 13, 2005 · Animal Model Preparation. All procedures were approved by the Indiana University Institutional Animal Care and Utilization Committee. The study was performed in a canine model of healed myocardial infarction (MI) and pacing-induced heart failure (HF) that was shown to have a high incidence of spontaneous ischemic ventricular …
WebMyocardial Akt levels were elevated in early heart failure (after 1-2 weeks of pacing) accompanied by increased levels of oxidative stress, cytokine tumor necrosis factor-alpha (TNF-alpha) and free fatty acid accumulation, reduced activity levels of mitochondrial respiratory complexes III and V and apoptosis initiation. WebApr 12, 2024 · Liu et al. used a rapid pacing model in vitro and a canine model of rapid pacing to establish the implication of miR-23a-3p in ferroptosis during AF. ... Yanni et al. used an animal model of heart failure that developed sinus bradycardia to demonstrate the function ... Lower levels of cardiac fibrosis are clinically associated with drug-induced ...
WebThe LVEDP increased and impedance decreased during pacing-induced heart failure and recovered after pacing cessation. At the end of pacing, there was a mean impedance reduction of 10.6 +/- 8.3% and a mean LVEDP increase of 18.1 +/- 4.5 mmHg compared to baseline. The impedance and LVEDP were inversely correlated (r =-0.41 to -0.85, all P < … WebTachypacing-induced heart failure is a well-established large animal model that recapitulates numerous pathophysiological, structural and molecular features of dilated …
WebMar 19, 1999 · Pacing-induced heart failure in the dog recapitulates many of the electrophysiological and hemodynamic abnormalities of the human disease; however, the mechanisms underlying altered Ca2+ handling have not been investigated in this model.
Web20 hours ago · Abnormal mitochondrial function in myocardium of dogs with chronic heart failure. J Mol Cell Cardiol. 1998; 30:1757–1762. doi: 10.1006/jmcc.1998.0739 Crossref Medline Google Scholar; 105. Marin-Garcia J, Goldenthal MJ, Moe GW. Abnormal cardiac and skeletal muscle mitochondrial function in pacing-induced cardiac failure. … bitcoin terms and conditionsWebTo further understand the cellular events and to clarify their role in the pathology of cardiac failure, we have examined mitochondrial enzymatic function and peptide content, and mitochondrial DNA (mtDNA) integrity in a canine model of pacing-induced cardiac failure. Methods: Myocardium and skeletal muscle tissues were evaluated for levels of ... dashboard admin bootstrap freeWebJul 10, 2024 · The development of pacing-induced heart failure was studied in chronically instrumented, conscious dogs paced at a rate of 240 beats/min for 1 d (n = 6), 1 wk (n = … dashboard ages covidWebJul 1, 2024 · The cardiac effects of pimobendan (but not amrinone) are preserved at rest and during exercise in conscious dogs with pacing-induced heart failure. J Pharmacol Exp Ther. (1997) 282:23–31. PubMed Abstract Google Scholar. ... 34. Powers JC, Recchia F. Canine model of pacing-induced heart failure. Methods Mol Biol. (2024) … dashboard aimmWebTachycardias can lead to ventricular contractile dysfunction, and rapid pacing is widely used to produce animal models of cardiomyopathy and atrial fibrillation . Abnormalities of cardiac Ca 2+ handling is one of the proposed mechanisms underlying the … dashboard admin templateWebBackground: The canine model of pacing-induced heart failure is characterized by an absence of ventricular hypertrophy despite severe hemodynamic stress and neurohormonal activation. Given the mode of ventricular pacing, hypertrophy might occur in the atrial appendage. Methods and results: Seventeen dogs underwent continuous right … dashboard add in for excelWebDec 1, 2010 · Canine model of pacing-induced HF. All animal study protocols were approved by the Institutional Animal Care and Use Committee of Indiana University … dashboard agfeo download